Rabbit Anti-CROCC/FITC Conjugated antibody

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ciliary rootlet coiled coil; Ciliary rootlet coiled-coil protein; Crocc; CROCC_HUMAN; KIAA0445; Rootletin.

Cat:

SL14066R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human CROCC

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

228kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

background:
CROCC is a 2017 amino acid protein that forms centriole-associated fibrous structures and is an essential component of the ciliary rootlet. Localized to basal bodies and centrosomes in ciliated and nonciliated cells, respectively, Rootletin associates with the proximal ends of basal bodies and, in photoreceptors, functions to form elongated polymers between them. Rootletin is required for centrosome cohesion and, through interaction with SLCNap1 (a centrosomal protein present at the ends of the centrioles), can regulate the linkage of centrioles to basal bodies. Rootletin exists as a homopolymer whose association with centrosomes can be regulated via phosphorylation by Nek2 (NIMA-related kinase 2). Two isoforms exist due to alternative splicing events.

Function:
Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis.

Post-translational modifications:
Phosphorylated by NEK2 which may regulate its association with centrosomes. Phosphorylated upon DNA damage, probably by ATM or ATR.

DISEASE:
Cytoplasm; cytoskeleton; centrosome; centriole. In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase.

Similarity:
Belongs to the rootletin family.

Database links:

Entrez Gene: 9696 Human

SwissProt: Q5TZA2 Human

Unigene: 309403 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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