The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF). This gene is located in a chromosomal region that is thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008]
Function:
May function as a transcription factor involved in cell differentiation.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in many tissues. Highly expressed in ovary, testis, pancreas, brain, heart and prostate.
Similarity:
Contains 6 C2H2-type zinc fingers.
Contains 1 SET domain.
SWISS:
Q9UKN5
Gene ID:
11108
Database links:
Entrez Gene: 11108 Human
Entrez Gene: 72843 Mouse
Entrez Gene: 170820 Rat
Omim: 605780 Human
SwissProt: Q9UKN5 Human
SwissProt: Q80V63 Mouse
SwissProt: Q9QZP2 Rat
Unigene: 506655 Human
Unigene: 25307 Mouse
Unigene: 162921 Rat
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