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Rabbit Anti-Timeless antibody
The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]
Function:
Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.
Subunit:
Homodimer or homomultimer.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus and testis.
Similarity:
Belongs to the timeless family.
SWISS:
Q9UNS1
Gene ID:
8914
Database links:
Entrez Gene: 522884 Cow
Entrez Gene: 8914 Human
Entrez Gene: 21853 Mouse
Entrez Gene: 83508 Rat
Omim: 603887 Human
SwissProt: Q9UNS1 Human
SwissProt: Q9R1X4 Mouse
SwissProt: Q9Z2Y1 Rat
Unigene: 118631 Human
Unigene: 6458 Mouse
Unigene: 31755 Rat
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