Alpha-CP1;
Heterogeneous nuclear ribonucleoprotein E1;
heterogenous nuclear ribonucleoprotein E1;
heterogenous nuclear ribonucleoprotein X;
hnRNP E1;
hnRNP-E1;
hnRNP-X;
HNRPE1;
HNRPX;
nucleic acid binding protein sub 2.3;
Nucleic acid- binding p
Cat:
SL19907R
Species Reactivity：
(predicted: Human,Mouse,Pig,Cow,Horse,)
Immunogen：
KLH conjugated synthetic peptide derived from human PCBP1:201-300/356
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]
Function: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.
Subcellular Location: Nucleus. Cytoplasm. Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.
Tissue Specificity: Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands.
Specific References (1) | SL19907R has been referenced in 1 publications.
[IF=6.17] Qian Wang. et al. Efficient iron utilization compensates for loss of extracellular matrix of ovarian cancer spheroids. Free Radical Bio Med. 2021 Feb;164:369 IF,IHC ; Human.
