This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010]
Function:
Probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Plays a role in ciliogenesis.
Subcellular Location:
Cell junction > focal adhesion. Cell membrane. Cytoplasm > cytoskeleton. Constituent of focal adhesions.
Tissue Specificity:
Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.
Similarity:
Belongs to the parvin family.
Contains 2 CH (calponin-homology) domains.
SWISS:
Q9NVD7
Gene ID:
55742
Database links:
Entrez Gene: 55742 Human
Entrez Gene: 57342 Mouse
Entrez Gene: 57341 Rat
Omim: 608120 Human
SwissProt: Q9NVD7 Human
SwissProt: Q9EPC1 Mouse
SwissProt: Q9HB97 Rat
Unigene: 432914 Human
Unigene: 143763 Mouse
Unigene: 92564 Rat
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