This gene encodes a member of the myristoylated alanine-rich SLCkinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012]
Function:
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems.
Subunit:
Binds to filamentous actin (F-actin), but not to monomeric G-actin, independently of its phosphorylation status.
Subcellular Location:
Cytoplasm By similarity. Cell membrane
Post-translational modifications:
Phosphorylation at Ser-120 and Thr-178 are non-redundantly catalyzed by MAPK8 in vivo. Phosphorylation at Thr-148 is preferentially catalyzed by MAPK8 in vivo, but this modification can also be catalyzed by other kinases in the absence of MAPK8
Similarity:
Belongs to the MARCKS family.
SWISS:
P9806
Gene ID:
65108
Database links:
Entrez Gene: 65108 Human
Entrez Gene: 17357 Mouse
Entrez Gene: 100366048 Rat
Entrez Gene: 81520 Rat
Omim: 602940 Human
SwissProt: P9806 Human
SwissProt: P28667 Mouse
SwissProt: Q9EPH2 Rat
Unigene: 707012 Human
Unigene: 75061 Human
Unigene: 424974 Mouse
Unigene: 2486 Rat
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