The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010]
Function:
May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.
Tissue Specificity:
Isoform 2 and isoform 3 are widely expressed. Isoform 2 highest levels are observed in fetal brain, and isoform 3 highest levels in pancreas, peripheral blood leukocytes, fetal brain and spleen.
Similarity:
Belongs to the protein kinase superfamily.
STE Ser/Thr protein kinase family.
MAP kinase kinase kinase subfamily.
Contains 1 protein kinase domain.
SWISS:
Q6ZN16
Gene ID:
389168
Database links:
Entrez Gene: 389168 Human
Entrez Gene: 270672 Mouse
Omim: 300820 Human
SwissProt: Q6ZN16 Human
SwissProt: A2AQW0 Mouse
Unigene: 713701 Human
Unigene: 386889 Mouse
|
|
