Rabbit Anti-MFHA1/Malignant fibrous histiocytoma antibody

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Malignant fibrous histiocytoma-amplified sequence 1; Malignant fibrous histiocytoma-amplified sequence with leucine-rich tandem repeats 1; MFHA1_HUMAN; Mfhas1.

Cat:

SL18128R

Species Reactivity：

(predicted: Human,Mouse,Dog,)

Immunogen：

KLH conjugated synthetic peptide derived from human MFHA1/Malignant fibrous histiocytoma:951-1052/1052

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Identified in a human 8p amplicon, this gene is a potential oncogene whose expression is enhanced in some malignant fibrous histiocytomas (MFH). The primary structure of its product includes an ATP/GTP-binding site, three leucine zipper domains, and a leucine-rich tandem repeat, which are structural or functional elements for interactions among proteins related to the cell cycle, and which suggest that overexpression might be oncogenic with respect to MFH. [provided by RefSeq, Jul 2008]

Tissue Specificity:
Ubiquitously expressed. Overexpressed in malignant fibrous histiocytomas.

DISEASE:
A chromosomal aberration involving MFHAS1 may be a cause of B-cell lymphoma. Translocation t(8;14)(p23.1;q21) with a cryptic exon named '14q21 element'. The resulting fusion protein named 'chimeric MASL1' is tumorigenic in nude mice.

Similarity:
Contains 13 LRR (leucine-rich) repeats.
Contains 1 Roc domain.

SWISS:
Q9Y4C4

Gene ID:
9258

Database links:

Entrez Gene: 9258 Human

Entrez Gene: 52065 Mouse

Entrez Gene: 306508 Rat

SwissProt: Q9Y4C4 Human

SwissProt: Q3V1N1 Mouse

Unigene: 379414 Human

Unigene: 103246 Mouse

Unigene: 106316 Rat

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