Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Function:
Component of the elastin-associated microfibrils.
Subcellular Location:
Secreted > extracellular space > extracellular matrix.
Post-translational modifications:
Forms intermolecular disulfide bonds either with other MAGP-1 molecules or with other components of the microfibrils. May form transglutaminase cross-links.
O-glycosylated.
Similarity:
Belongs to the MFAP family.
Contains 1 SXC (ShKT) domain.
SWISS:
P55001
Gene ID:
4237
Database links:
Entrez Gene: 4237 Human
Entrez Gene: 17150 Mouse
Entrez Gene: 313662 Rat
Omim: 156790 Human
SwissProt: P55001 Human
SwissProt: P55002 Mouse
Unigene: 389137 Human
Unigene: 7386 Mouse
Unigene: 17012 Rat
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