This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008]
Function:
Element of the mTORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
Subcellular Location:
Nucleus. Cytoplasm.
Post-translational modifications:
Phosphorylated at Ser-60, Ser-68 and Ser-75; the major sites of phosphorylation. Nuclear accumulation correlates with a concomitant dephosphorylation. Phosphorylation may attenuate its RNA polymerase III-repressive function.
Similarity:
Belongs to the MAF1 family.
SWISS:
Q9H063
Gene ID:
84232
Database links:
Entrez Gene: 84232 Human
Entrez Gene: 68877 Mouse
Entrez Gene: 315093 Rat
Omim: 610210 Human
SwissProt: Q9H063 Human
SwissProt: Q9D0U6 Mouse
SwissProt: Q5XIH0 Rat
Unigene: 19673 Human
Unigene: 289136 Mouse
Unigene: 1113 Rat
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