This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008]
Function:
Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.
Subcellular Location:
Nucleus.
Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain.
SWISS:
Q14582
Gene ID:
10608
Database links:
Entrez Gene: 10608 Human
Entrez Gene: 17122 Mouse
Entrez Gene: 72961 Rat
SwissProt: Q14582 Human
SwissProt: Q60948 Mouse
Unigene: 10482 Human
Unigene: 655020 Human
Unigene: 259260 Mouse
Unigene: 391777 Mouse
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