The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. [provided by RefSeq, Jul 2008]
Function:
Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane.
Subcellular Location:
Mitochondrion outer membrane.
Tissue Specificity:
AKAP149 is highly expressed in prostate and small intestine whereas S-AKAP84 is expressed in kidney, pancreas, liver, lung and brain. AKAP149 is also expressed in colon carcinoma.
Similarity:
Contains 1 KH domain.
Contains 1 Tudor domain.
SWISS:
Q92667
Gene ID:
8165
Database links:
Entrez Gene: 8165 Human
Omim: 602449 Human
SwissProt: Q92667 Human
Unigene: 463506 Human
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