Rabbit Anti-COQ10B antibody

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Coenzyme Q10; Coenzyme Q10 B; Coenzyme Q10 homolog B; Coenzyme Q10B; CQ10B_HUMAN.

Cat:

SL11656R

Species Reactivity：

Human,Mouse,(predicted: Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep,Orangutan)

Immunogen：

KLH conjugated synthetic peptide derived from human COQ10B:38-110/238

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample: HepG2(Human) Cell Lysate at 30 ugHL60(Human) Cell Lysate at 30 ugPrimary: Anti- COQ10B (SL11656R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 23 kDObserved band size: 26 kDSample: Hela(Human) Cell Lysate at 30 ugTestis (Mouse) Lysate at 40 ugHeart (Mouse) Lysate at 40 ugPrimary: Anti- COQ10B (SL11656R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 23 kDObserved band size: 26 kDSample: Lung (Mouse) Lysate at 40 ugPrimary: Anti- COQ10B (SL11656R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 23 kDObserved band size: 23 kDSample: Cerebellum (Mouse) Lysate at 40 ugPrimary: Anti- COQ10B (SL11656R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 23 kDObserved band size: 25 kD

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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COQ10B, Coenzyme Q10, is a 247 amino acid protein encoded by the human gene COQ10B. COQ10B is a mitochondrial protein that belongs to the COQ10 family. COQ10B is an essential biological cofactor which increases brain mitochondrial concentration and exerts neuroprotective effects. Plasma COQ10B levels decrease in patients with advanced chronic heart failure (CHF) while COQ10B levels in hyperthyroid patients are found among the lowest detected in human diseases. Likewise, COQ10B is elevated in hypothyroid subjects, also in subclinical conditions, suggesting the usefulness of this index in assessing metabolic status in thyroid disorders. It is believed that secretion of adrenal hormones is in some way related to COQ10B levels, both in augmented and reduced conditions. However, since thyroid hormones have an important role in modulating COQ10B levels and metabolism, when coexistent, thyroid deficiency seems to play a prevalent role in comparison with adrenal deficiency.

Function:
COQ10 (Coenzyme Q10) is found in a wide variety of foods and is synthesized in all tissues. The de novo biosynthesis of COQ10, from its precursor tyrosine, is a multistage process that requires at least eight vitamins and several trace elements. More complex enzymes have an absolute dependancy on 'cofactors', a large group of molecules to which the coenzymes belong, for their catalyitic function. Coenzyme Q10 is the cofactor for, but not limited to, several mitochondrial enzymes that are central to the supply of adenosine triphosphate (ATP). In addition, COQ10 in its reduced form is a potent antioxidant, and in this capacity, a reduction in COQ10 levels are associtated with a variety of degenerative process including skin aging and neurodegenerative conditions such as Alzhiemer's, Huntingdon's and Parkinson's diseases.

Subunit:
Interacts with coenzyme Q

Subcellular Location:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side

Similarity:
Belongs to the COQ10 family.

SWISS:
Q9H8M1

Gene ID:
80219

Database links:

Entrez Gene: 80219 Human

Entrez Gene: 67876 Mouse

SwissProt: Q9H8M1 Human

SwissProt: Q3THF9 Mouse

SwissProt: Q5I0I9 Rat

Unigene: 632547 Human

Picture

Sample:
Hela(Human) Cell Lysate at 30 ug
Testis (Mouse) Lysate at 40 ug
Heart (Mouse) Lysate at 40 ug
Primary: Anti- COQ10B (SL11656R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 23 kD
Observed band size: 26 kD

Sample:
Lung (Mouse) Lysate at 40 ug
Primary: Anti- COQ10B (SL11656R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 23 kD
Observed band size: 23 kD

Sample:
Cerebellum (Mouse) Lysate at 40 ug
Primary: Anti- COQ10B (SL11656R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 23 kD
Observed band size: 25 kD

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