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Rabbit Anti-DNAJC2/FITC Conjugated antibody
background:
This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Function:
Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGSLC3'.
Subcellular Location:
Nucleus. Cytoplasm > cytosol.
Tissue Specificity:
Widely expressed.
Post-translational modifications:
Phosphorylated in M (mitotic) phase.
Similarity:
Contains 1 J domain.
Contains 2 SANT domains.
Database links:
Entrez Gene: 27000 Human
Entrez Gene: 507897 Cow
Entrez Gene: 22791 Mouse
Entrez Gene: 116456 Rat
Omim: 605502 Human
SwissProt: Q1RMH9 Cow
SwissProt: Q99543 Human
SwissProt: P54103 Mouse
SwissProt: Q7TQ20 Rat
Unigene: 558476 Human
Unigene: 266312 Mouse
Unigene: 11908 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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