Rabbit Anti-GADD34/FITC Conjugated antibody

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Growth arrest and DNA damage-inducible 34; Apoptosis associated protein; GADD 34; Growth arrest and DNA damage inducible 34; Growth arrest and DNA-damage-inducible 34; PPP1R15A; Protein phosphatase 1 regulatory (inhibitor) subunit 15A; Protein phosphatase

Cat:

SL10287R-FITC

Species Reactivity：

Human,(predicted: Mouse,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human GADD34

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

Flow-Cyt=1:50-200ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

74kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008]

Function:
Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress.

Subunit:
Interacts with PCNA. Interacts with LYN and MLL. Interacts with PP1, PPP1R1A and SMARCB1. Interacts with SMAD7. Interacts with BAG1.

Subcellular Location:
Endoplasmic reticulum.

Post-translational modifications:
Phosphorylated on tyrosine by LYN; which impairs its antiproliferative activity.

Similarity:
Belongs to the PPP1R15 family.

Database links:

Entrez Gene: 514688 Cow

Entrez Gene: 23645 Human

Entrez Gene: 17872 Mouse

Entrez Gene: 171071 Rat

Omim: 611048 Human

SwissProt: Q2KI51 Cow

SwissProt: O75807 Human

SwissProt: P17564 Mouse

SwissProt: Q6IN02 Rat

Unigene: 631593 Human

Unigene: 4048 Mouse

Unigene: 2232 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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