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Rabbit Anti-CRLF3/FITC Conjugated antibody
background:
This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012]
Function:
CRLF3 (Cytokine receptor-like factor 3) contains one fibronectin type-III domain. It is expressed in skin and squamous cell carcinoma (SCC) and in lesion actinic keratosis (AK).
Subcellular Location:
Cytoplasmic
Tissue Specificity:
Expressed in several embryonic and adult tissues, including adult and fetal brain, liver, spleen and pancreas. Expressed in adult, but not fetal kidney. Expressed in skin and squamous cell carcinoma (SCC) and in several other cancer types. Also detected in lesion actinic keratosis (AK).
Similarity:
Belongs to the cytokine receptor-like factor 3 family.
Contains 1 fibronectin type-III domain.
Database links:
Entrez Gene: 51379 Human
Entrez Gene: 54394 Mouse
Omim: 614853 Human
SwissProt: Q8IUI8 Human
SwissProt: Q9Z2L7 Mouse
Unigene: 649372 Human
Unigene: 272093 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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