Rabbit Anti-Troponin T-Slow Skeletal/FITC Conjugated antibody

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Troponin T-SS; Cardiac muscle troponin T-Slow Skeletal; Cardiac Troponin T-Slow Skeletal; TNNT1_HUMAN.

Cat:

SL7366R-FITC

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human Troponin T-Slow Skeletal

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

33kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Actin is a highly conserved protein that is expressed in all eukaryotic cells and interacts with Myosin to generate the force for diverse cellular movements, including cytokinesis, phagocytosis and muscle contraction. Troponin facilitates the interaction between Actin and Myosin by binding to calcium. Troponin is made up of at least two subunits, which are divergent in cardiac muscle, fast skeletal muscle and slow skeletal muscle. Structures of skeletal muscle Troponin are composed of Troponin C (the sensor), Troponin I (the regulator) and three Troponin T (the link to the muscle thin filament) proteins, one of which functions as a Tropomyosin-binding protein and is known as Troponin T-SS (Troponin T-Slow Skeletal). Defects in the gene encoding Troponin T-SS are the cause of nemaline myopathy type 5 (NEM5), a form of nemaline myopathy characterized by mild contractures of the shoulders and hips, tremors and respiratory problems that often lead to death. Troponin T-SS is expressed as three isoforms due to alternative splicing events.

Function:
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Similarity:
Belongs to the troponin T family.

Database links:

Entrez Gene: 7138 Human

Omim: 191041 Human

SwissProt: P2765 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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