Rabbit Anti-COPT2/FITC Conjugated antibody

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AI604396; Copper transporter 2; COPT2; COPT2_HUMAN; CTR2; hCTR2; MGC117640; Probable low affinity copper uptake protein 2; RP23 64F17.2; SLC31A2; Solute carrier family 31 member 2; Solute carrier family 31, member 2.

Cat:

SL13981R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human COPT2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

16kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The activity of a diverse subset of enzymes relies on the essential nutrient copper to perform important processes including signaling to the transcription and protein trafficking machinery, oxidative phosphorylation, iron mobilization, neuropeptide maturation, and normal development. Copper uptake requires tight regulation to ensure that sufficient copper is present in the cell to drive vital cellular processes, while avoiding the accumulation of copper to toxic levels. The copper transporter 2 (COPT2), also designated CTR2 or Solute carrier family 31 member 2 (SLC31A2), is a 143 amino acid protein mediates the uptake of copper in mammalian cells. COPT2 has been shown to localize to the plasma membrane, endosomes and lysosomes, where it plays a role in maintaining copper homeostasis. COPT2 also mediates the uptake of the chemotherapeutic drugs cisplatin and carboplatin and may modulate the sensitivity and toxicity of these drugs.

Function:
Involved in low-affinity copper uptake.

Subcellular Location:
Membrane.

Tissue Specificity:
Ubiquitous.

Similarity:
Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.

Database links:

Entrez Gene: 1318 Human

Entrez Gene: 20530 Mouse

Omim: 603088 Human

SwissProt: O15432 Human

SwissProt: Q9CPU9 Mouse

Unigene: 4830 Human

Unigene: 292539 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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