Rabbit Anti-KIAA1462/FITC Conjugated antibody

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JCAD; Junctional protein associated with coronary artery disease; JCAD_HUMAN; KIAA1462; Uncharacterized protein KIAA1462.

Cat:

SL13762R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human KIAA1462

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

148kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
KIAA1462 is a 1,359 amino acid protein that colocalizes with VE-Cadherin specifically in endothelial cells and not epithelial cells. KIAA1462 is post-translationally phosphorylated at four serine residues and is in involved celluar adhesion. The gene encoding KIAA1462 maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. The chromosome 10 encoded gene ERCC6 is important for DNA repair and is linked to Cockayne syndrome which is characterized by extreme photosensitivity and premature aging. Tetrahydrobiopterin deficiency and a number of syndromes involving defective skull and facial bone fusion are also linked to chromosome 10. As with most trisomies, trisomy 10 is rare and is deleterious.

Subcellular Location:
Cell junction, adherens junction (By similarity). Note=Colocalizes with VE-Cadherin, in endothelial cells but not in epithelial cells (By similarity).

Database links:

Entrez Gene: 57608 Human

SwissProt: Q9P266 Human

Unigene: 533953 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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