Rabbit Anti-TWEAK/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-TWEAK/FITC Conjugated antibody

CD 255; CD255; APO 3 ligand; APO 3L; APO3 ligand; APO3/DR3 ligand; APO3L; DR3LG; MGC129581; MGC20669; secreted form; TNF related weak inducer of apoptosis; TNF-related weak inducer of apoptosis; TNF12_HUMAN; TNFRS12a; TNFSF 12; TNFSF12; TNFSF12 protein; T

Cat:

SL13770R-FITC

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human TWEAK/CD255

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

37kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
Proteins belonging to the tumor necrosis factor (TNF) superfamily are potent mediators of inflammation and of the immune system. Members of the TNF superfamily include TNFβ, lymphotoxin β (LTb), CD154 (CD40L), CD30L, CD27L, OX40L, 4-1BBL, FAS-L (APO-1) and TRAIL. Most TNF family members are type II transmembrane proteins that are proteolytically processed at their carboxy terminal extracellular domain to form a soluble homotrimeric molecule. TWEAK (also designated Apo-3L) has been identified as a secreted ligand belonging to the TNF superfamily. TWEAK seems to induce apoptosis weakly, and it may be involved in cell differentiation in vivo.

Function:
Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.

Subunit:
Homotrimer (Probable). Interacts with the angiogenic factor AGGF1/VG5Q.

Subcellular Location:
Secreted and Cell membrane.

Tissue Specificity:
Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.

Post-translational modifications:
The soluble form derives from the membrane form by proteolytic processing.

Similarity:
Belongs to the tumor necrosis factor family.

Database links:

Entrez Gene: 8742 Human

Entrez Gene: 21944 Mouse

Entrez Gene: 72548 Rat

Omim: 602695 Human

SwissProt: O43508 Human

SwissProt: O54907 Mouse

Unigene: 54673 Human

Unigene: 8983 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall