Rabbit Anti-phospho-ZCWCC1 (Ser739)/FITC Conjugated antibody

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AC004542.C22.1.; p-MORC2(Ser739); phospho-ZCWCC1(Ser739); CW type with coiled coil domain 1; KIAA0852; ZCW3; ZCWCC1; Zinc finger; Zinc finger CW type coiled coil domain protein 1; Zinc finger CW type with coiled coil domain 1; Zing finger CW type 3 zinc f

Cat:

SL10016R-FITC

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthesised phosphopeptide derived from human MORC2 around the phosphorylation site of Ser739

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

114kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The CW domain is a structural module found in many vertebrate, parasitic and plant proteins. It consists of a mononuclear four-cysteine zinc-finger domain that plays a role in DNA binding, chromatin methylation and early embryonic development. ZCWCC1 (zinc finger CW-type coiled-coil domain protein 1), also known as MORC2 (MORC family CW-type zinc finger protein 2) or ZCW3, is a 1,032 amino acid protein that contains one CW-type zinc finger domain. ZCWCC1 is located on chromosome 22 and is ubiquitously expressed with highest expression in pancreas, smooth muscle and testis. Expression of ZCWCC1 is upregulated in hypoxia, a pathological condition characterized by an inadequate supply of oxygen in the blood.

Function:
May act as a transcriptional repressor. Down-regulates CA9 expression.

Subunit:
Interacts with HDAC4.

Subcellular Location:
Nucleus. Cytoplasm, cytosol. Note=Mainly located in the nucleus.

Tissue Specificity:
Highly expressed in smooth muscle, pancreas and testis.

Similarity:
Contains 1 CW-type zinc finger.

Database links:
UniProtKB/Swiss-Prot: Q9Y6X9.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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