Rabbit Anti-CALHM1/FITC Conjugated antibody

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CAHM1_HUMAN; Calcium homeostasis modulator 1; Calcium homeostasis modulator protein 1; CALHM1; FAM26C; Family with sequence similarity 26, member C; MGC39514; MGC39617; Protein FAM26C.

Cat:

SL11642R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human CALHM1/FAM26C

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

38kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010].

Function:
May be a pore-forming ion channel. Controls cytosolic Ca(2+) permeability and cytosolic Ca(2+) concentration. Controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner.

Subunit:
Homooligomer; homomultimerized to form dimeric and possibly tetrameric structures.

Subcellular Location:
Cell membrane. Endoplasmic reticulum membrane. Colocalizes with HSPA5 at the endoplasmic reticulum.

Tissue Specificity:
Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells.

Similarity:
Belongs to the FAM26 family.

Database links:

Entrez Gene: 255022 Human

Entrez Gene: 546729 Mouse

Entrez Gene: 499367 Rat

Omim: 612234 Human

SwissProt: Q8IU99 Human

Unigene: 136365 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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