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Rabbit Anti-Puratrophin 1/FITC Conjugated antibody
background:
The protein encoded by this gene contains multiple domains suggestive of a role in intracellular signaling and cytoskeleton dynamics at the Golgi apparatus. Mutations in this gene are associated with spinocerebellar ataxia 16q22-linked. Several alternatively spliced transcript variants, differing only in the 5' UTR, or encoding a different isoform, have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Expressed in kidney, Leydig cells in the testis, epithelial cells in the prostate gland and Langerhans islet in the pancreas. Isoform 1 and isoform 3 are strongly expressed in Purkinje cells and to a lower extent in other neurons (at protein level). Widely expressed at low levels. More strongly expressed in testis and pancreas.
Tissue Specificity:
Expressed in kidney, Leydig cells in thetestis, epithelial cells in the prostate gland and Langerhans isletin the pancreas. Isoform 1 and isoform 3 are strongly expressed inPurkinje cells and to a lower extent in other neurons (at proteinlevel). Widely expressed at low levels. More strongly expressed intestis and pancreas.
Similarity:
Contains 1 DH (DBL-homology) domain.
Contains 1 PH domain.
Database links:
Entrez Gene: 25894 Human
Omim: 609526 Human
SwissProt: Q58EX7 Human
Unigene: 188781 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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